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erythroriv 200mg susp fl-100ml
Erythroriv 200mg
Erythroriv
Description:
Erythromycin belongs to the macrolide group of antibiotics. Erythromycin ethylssuccinate is an ester of erythromycin suitable for oral administration.
Compotation:
Erythroriv Suspension: Each 5 ml of the reconstitute suspension contains 250 mg, 200 mg or 125 mg of erythromycin. Excipients: Xanthus gum – Methyl parable sodium -propels parable sodium – Strawberry flavor Disodium citrate – Aerosil Sucrose, titanium Dioxide and vanillin, saccharine sodium. Sodium metabisulphite
Clinical pharmacology:
·Orally administered erythromycin ethyl succinct is readily and reliably absorbed under both fasting and no fasting conditions. It diffuses readily in most of body fluids.
• Only low concentrations are normally achieved in the ~penal fluid. But passage of the drug across blood- brain barrier increases in meningitis.
• In the presence of normal hepatic function. Erythromycin IS concentrated in the liver and excreted in the bile. Less than 5 percent of the orally administered dose of erythromycin is excreted in active form in the urine.
• Erythromycin crosses the placental barrier. But total plasma levels are low. The drug is excreted in human milk.
Microbiology:
-Erythromycin acts by inhibition of protein synthesis by binding SO S ribosomal subunit of susceptible organisms. It does not affect nucleic add synthesis. Antagonism has been demonstrated between clindamycin and erythromycin.
– Many strains of H.lnfluenzae are resistant to erythromycin alone but are susceptible to erythromycin and sulfonamides used concomitantly.
Erythromycin has been shown to be active against most strains of the following microorganisms:
Gram-posative organisms:
• Corynebacterium diphtheria • Corynebacterium minutissimum
· Listeria monocytogenes • Staphylococcus aureus.
· Streptococcus pneumoniae, streptococcus pyogenes.
Gram – negative organisms:
· Bordetella pertussis legionella pneumophila
· Neisseria gonorrhoeae.
Other organisms:
Chlamydia trachomatis.
Entamoeba hIstoIytlca.
MycoplaSma pneumonia.
Treponema pallidum.
Ureaplasma urealyticum.
Indications and usage :
Erythroriv
Is Indicated In the treatment of infections caused by susceptible strains of microorganisms in the
Following cases:
– Upper respiratory tract infections of mild to moderate degree.
Erythromycin ethylsuccinate
– Lower respiratory tract Infections of mild to moderate
Severity
– LiSteriosis.
– Perusals (whooping cough).
– Respiratory tract Infections due to Mycoplasma
Pneumonia.
– Skin and soft tissue Infections of mild to moderate
Severity.
– Diphtheria (as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers.
– Erythrasma, Intestinal am blasts, and primary syphilis.
– Erythromycins are Indicated In the treatment of the
Following Infections caused by Chlamydia trachmatis. conjunctivitis of the newbom, pneumonia of Infancy, urogenital infections during ‘pregnancy.
– When tetracycline are contraindicated or not tolerated, erythromycin is indicated it, the treatment of uncomplicated urethral, end cervical, or rectal Infections in adults due to Chlamydia trachmatis.
-legionnaires ‘disease. .
Prophylaxis:
– Prevention’ of initial attacks of Rheumatic fever (for penicillin -allergic patients).
– Prevention of recurrent attacks of Rheumatic fever. (For penicillin and sulphonamldes allergic patients).
Contralncllatlonl:
Erythromycin is contraindicated in patients with known hypersensitivity to this antibiotic or to patients taking terfenadlne,
Warning:
-Hepatic dysfunction Including Increased liver enzymes, and hepatocellular and/or cholestatic hepatitis with or without jaundice may occur during erythromycin therapy. – Erythromycin does not reach the fetus in adequate concentration to prevent congenital syphilis. -Pseudomembraneous colitis accompanies erythromycin therapy (as with most antimicrobial agents).
-Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia.
| Pharmacy | |
| Description | Erythroriv 200mg Erythroriv Description: Erythromycin belongs to the macrolide group of antibiotics. Erythromycin ethylssuccinate is an ester of erythromycin suitable for oral administration. Compotation: Erythroriv Suspension: Each 5 ml of the reconstitute suspension contains 250 mg, 200 mg or 125 mg of erythromycin. Excipients: Xanthus gum – Methyl parable sodium -propels parable sodium – Strawberry flavor Disodium citrate – Aerosil Sucrose, titanium Dioxide and vanillin, saccharine sodium. Sodium metabisulphite Clinical pharmacology: ·Orally administered erythromycin ethyl succinct is readily and reliably absorbed under both fasting and no fasting conditions. It diffuses readily in most of body fluids. • Only low concentrations are normally achieved in the ~penal fluid. But passage of the drug across blood- brain barrier increases in meningitis. • In the presence of normal hepatic function. Erythromycin IS concentrated in the liver and excreted in the bile. Less than 5 percent of the orally administered dose of erythromycin is excreted in active form in the urine. • Erythromycin crosses the placental barrier. But total plasma levels are low. The drug is excreted in human milk. Microbiology: -Erythromycin acts by inhibition of protein synthesis by binding SO S ribosomal subunit of susceptible organisms. It does not affect nucleic add synthesis. Antagonism has been demonstrated between clindamycin and erythromycin. – Many strains of H.lnfluenzae are resistant to erythromycin alone but are susceptible to erythromycin and sulfonamides used concomitantly. Erythromycin has been shown to be active against most strains of the following microorganisms: Gram-posative organisms: • Corynebacterium diphtheria • Corynebacterium minutissimum · Listeria monocytogenes • Staphylococcus aureus. · Streptococcus pneumoniae, streptococcus pyogenes. Gram – negative organisms: · Bordetella pertussis legionella pneumophila · Neisseria gonorrhoeae. Other organisms: Chlamydia trachomatis. Entamoeba hIstoIytlca. MycoplaSma pneumonia. Treponema pallidum. Ureaplasma urealyticum. Indications and usage : Erythroriv Is Indicated In the treatment of infections caused by susceptible strains of microorganisms in the Following cases: – Upper respiratory tract infections of mild to moderate degree. Erythromycin ethylsuccinate – Lower respiratory tract Infections of mild to moderate Severity – LiSteriosis. – Perusals (whooping cough). – Respiratory tract Infections due to Mycoplasma Pneumonia. – Skin and soft tissue Infections of mild to moderate Severity. – Diphtheria (as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. – Erythrasma, Intestinal am blasts, and primary syphilis. – Erythromycins are Indicated In the treatment of the Following Infections caused by Chlamydia trachmatis. conjunctivitis of the newbom, pneumonia of Infancy, urogenital infections during ‘pregnancy. – When tetracycline are contraindicated or not tolerated, erythromycin is indicated it, the treatment of uncomplicated urethral, end cervical, or rectal Infections in adults due to Chlamydia trachmatis. -legionnaires ‘disease. . Prophylaxis: – Prevention’ of initial attacks of Rheumatic fever (for penicillin -allergic patients). – Prevention of recurrent attacks of Rheumatic fever. (For penicillin and sulphonamldes allergic patients). Contralncllatlonl: Erythromycin is contraindicated in patients with known hypersensitivity to this antibiotic or to patients taking terfenadlne, Warning: -Hepatic dysfunction Including Increased liver enzymes, and hepatocellular and/or cholestatic hepatitis with or without jaundice may occur during erythromycin therapy. – Erythromycin does not reach the fetus in adequate concentration to prevent congenital syphilis. -Pseudomembraneous colitis accompanies erythromycin therapy (as with most antimicrobial agents). -Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. |
| Usage | Precaution: – Caution should be exercised when erythromycin is administered to patients with impaired hepatic function. – Erythromycin may aggravate the weakness of patients with myasthenia gravis. – Prolonged or repeated use of erythromycin may result in an overgrowth of nonsusceptlble bacteria or fung.lf super infection occurs, erythromycin should be discontinued and appropriate therapy is instituted. -laboratory tests: Erythromycin interferes with the flour metric determination of urinary catecholamines • DruY INTEATIONS: – Theophylline: Increase In serum theophylline levels and potential theophylline toxicity. -Digoxin: elevated digoxin serum levels. Dry suspension – Anticoagulants: increased anticoagulant effect. – Ergotamine and dihydroergotamine:acut ergot toxicity. – Benzodiazeplnes:erythromycin decrease the clearance of triazolam, midazolam. -Drugs metabolized by the CYtochrome P450:elevation serum levels. (carbamazepine, cycIosporlne, hexobarbital of phenytoin” terfenadlne). ‘ -Antihistamlnics (terfenadine) : erythromycin Significantly alter their metabolism. – Erythromycin therapy used only to pregnant women if clearly needed. -caution should be taken when erythromycin Is administered to nursing women because it Is excreted • human milk. In Adverse reactions: The most frequent side effects are gastolntestinal and are dose-refated. Gastointestinal: Nausea, vomiting, abdominal pain,dlarrhea and anorexia. live: Hepatitis, hepatic dysfunction and/or abnormal liver function tests C.V.S: rarely ventricular arrythmlasis. Allergic reactions: ranging from urticaria to anaphylaxis. Skin reactions: ranging from mild eruptions to erythema multiforme, Stevens-Johnsons syndrome and toxic epidermal necrolysls. _ Reversible hearing loss occurlng chiefly In patients with renal insufficiency and In patients receiving high doses of erythromycin. Dosage anti administration: Children: *Dose is dependent on age, weight, type and severity of the disease. *In mild to moderate Infectlons:the usual dosage is 30 – 50 mg / kg /day In equally divided doses every 6 hours. -For more severe cases : the dosage may be doubled • How supplied: Suspension . Dry powder to make 60 or 80 or 100 ml volume suspension each 5 ml of the reconstituted suspension contains the equivalent of 250 mg, 200 mg or 125 mg erythromycin. |
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Medical Products
- Product Code: 8120614
- Availability: In Stock
- Prescription: Prescription is Needed
- 2,485FCFA
- Ex Tax: 2,485FCFA
